Talk:Hypoxanthine

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Untitled[edit]

I was wondering with hypoxanthine as a base for DNA when nitrous acid has been removed, does this new base continue on for many generations or does the repair mechanisms of the DNA cancel it out so the DNA becomes 'normal' again.

Apparently, an enzyme named adenase converts the hypoxanthine back to adenine. I'm trying to study for an AP bio test, and found no information in my textbook, so I headed to Wikipedia to get the information. --Luigifan (talk) 17:24, 13 January 2008 (UTC)[reply]

IUPAC Name[edit]

The currently listed name 3,7-dihydropurin-6-one appears to refer to a tautomer of the illustrated structure, whereas the illustrated structure should be 1H-purin-6(9H)-one. If I had to guess, I would say that the IUPAC name listed came from the nominal structure produced by the CambridgeSoft ChemDraw Name-To-Structure feature, which also yields the 3,7-dihydro tautomer.

Please consult the image below to observe the tautomerism:

3,7-dihydropurin-6-one versus 1H-purin-6(9H)-one

In light of this discrepancy, I am changing the listed IUPAC name to 1H-purin-6(9H)-one such that it is analogous in hydrogenation to the listed isomers of guanine and adenine, i.e. as if they had nucleosidic glycosylation at position 9 replaced with a proton.. Eutactic (talk) 05:17, 12 January 2009 (UTC)[reply]

I endorse homogenising hypoxanthine with the representations of the other nucleobases guanine and adenine and with the image provided and thus listing 1H-purin-6(9H)-one, as it may appear in - for instance - inosine. As such I am changing the SMILES to match and attempting to find a less ambiguous PubChem entry. Eutactic (talk) 05:58, 12 January 2009 (UTC)[reply]