Talk:Late-onset hypogonadism

Why "Late Onset"?

Is this a recognised condition in younger men, hence a normal or early onset is supposed to exist? 2.28.151.167 (talk) 09:48, 2 February 2018 (UTC)

Expert help

Some expert help is needed with this article as to what extent male menopause is even recognized as a clinical entity. Also one editor has claimed that "Regardless of nomenclature, doctors agree that the loss of hormones can be a painful and often life-altering affliction, whether it is experienced by women or men." First off, this is a Wikipedia weasel phrase... plus I don't think that doctors agree with this statement. All the doctors I have talked to say that male menopause does not exist. Help please? Invertzoo (talk) 18:15, 16 December 2007 (UTC)

Tom Hanks

Why is his picture randomly displayed? — Preceding unsigned comment added by 170.232.128.10 (talk) 18:46, 20 October 2014 (UTC)

Possibly because the film "Splash", which he starred in, is a remake of "Mr Peabody and the Mermaid", a film revolving around the "male menopause", though it seems a bit tenuous. 2.28.151.167 (talk) 09:54, 2 February 2018 (UTC)

Neutrality

This article has problems with NPV, amongst other things.Invertzoo (talk) 15:17, 12 December 2007 (UTC)

Article Update

It's my first Wiki entry any feedback and edits appreciated. Especially regarding references... Going to mess with it more tomorrow. Cleaned up somebody esle's external refs as a bulleted list. Is this convention?

Hacel 19:24, 25 June 2007 (UTC)

Hi Hacel,

There appears to be a complete misunderstanding of the term Andropause. It is a word of convenience to describe the stage of an aging mans life. It's normal and natural for men to lose 1-2% of their total testosterone per decade.

The reason it's not in the WHO dictionary is that it *ITSELF* is not a disease. What becomes a disease of the Andropause stage is hypogonadalism, where that steady declince of Total Testosterone level drops below an age-specific reference range.

In these two articles we see the name Andropause incorrectly being used interchangeable:

http://ajp.psychiatryonline.org/cgi/content/abstract/155/10/1310

http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=11212438

So its better to think of Andropause as the setting sun, when we still see the glow, and feel the heat. Hypogonolasm is the state of deficincy, where it has gotton too low and dim to provide what is normally needed.. At the other end of the spectrum, are the abuses, bodybuilders who double, triple or use 10, 100x as much as anyone every needs in their bodies.

I suggest we merge this article into Hypogodolism.—Preceding unsigned comment added by Wilfredtr (talk • contribs) 03:41, 16 September 2009 (UTC)

References

Information or Drug Companies?

The only Reference as of this note, http://www.e-juven8.com/male%20amdropause.asp, contains a lot of text from the first External Link, http://www.andropause.com, which seems to be one of those cleverly disguised pharmaceutical sites posing as an information site. Andropause.com seems to be pushing the drug Andriol. Despite the admitted fuzzy causation of andropause, the Diagnosis section and the subject of many of the links seems to suggest that hormonal replacement is the only option. Some authoritative "alternative" additions to this article would be more useful.

Yes, it's a classic cut-and-paste sign when you see pages of detailed information, yet no wikilinks. I personally don't care much for a wiki article that is just a copy of a reference. I mean, this is the internet, right? I say delete the copied text and let the article be without it. Rhetth 00:14, 7 February 2007 (UTC)

Ditto. I was going to post the same complaint. Other refs that might be more reliable:

http://www.andropause.org.uk/

http://www.wellnessmd.com/andropause.html

http://www.andropause.ca/en/index.asp

http://emas.obgyn.net/

Sundaybrunch 17:21, 1 April 2007 (UTC)

Seems to me that they should call it womanopause just to be fair. My guess is eventually all men go through it if they live long enough. First sign being erectile disfunction. No man wants to admit it. Not alot of statistics to prove it.

Working on this article bit by bit. If you notice my formatting errors, please let me know or fix them. Pretty new to wiki editing.

Hacel 19:26, 25 June 2007 (UTC)

Acupuncture, Chinese medicine, herbal treatments,

I, perhaps temporarily, moved this content on "Treatments" to ths page:

• Acupuncture, Chinese medicine, herbal treatments,

The reason is that it is controversial, and I think a discussion of it is needed before displaying it, because such alternative medicine is doubted to have any positive effects. The facts are referenced, that is true, but the link didn't lead to any page where this certain information was found. Rather, it directed to an offering to buy a book, and it feels unnecessary to buy a whole book just to check for its references. Every such information ultimately needs references to experimental trials, but I couldn't find any such study, linking alternative medicine and andropause together when searching the NCBI databases. Perhaps I didn't search accurately enough. Perhaps that study wasn't puplished yet. Anyhow, if you want the claim republished in the article, please give me directions to any studies indicating the effectiveness of such effects. Mikael Häggström 13:45, 2 July 2007 (UTC)

Herbal Medicine

It is awkward to avoid copyright violation and create enough credibility in these pages, so I can't scan in and show the page in Lexicomp's drug, herb and cytochrome interaction handbook ISBN 1-59195-089-9 detailing St John's Wort as an inducer of CYP3A4 (it boosts the performance of the enzyme) but believe me it's there, perhaps someone can find an external credible web site to reference. It can be seen on the CYP3A4 page that St John's Wort is listed as an inducer (speeds up/boosts)

As many people know St John's wort is useful in treating depression, and it's no conincidence that men with andropause get depression. Current drugs like SSRI's and SNRI's effect the amount of neurotransmitters in the brain, thus treating the symptoms of depression.

St John's Wort and probably other herbs that haven't been tested yet treats (one of?) the cause(s) of depression by boosting CYP3A4 thus speeding up toxin removal from the body, and helping to boost 4-OHAD back to "normal levels", thus lowering CYP19 levels and boosting free testosterone levels.

Just for clarity I'm not saying that all causes of depression are caused by lack of free testosterone in the body, I don't know anything about other causes of depression.

Perhaps when we get a credible reference to put on the main page we can get Hacel's comment regarding herbs put back on the main page, not sure about the acupuncture comment however!

---

this article is completely unscientific--this looks like it was written by some self-help guru.

Much of the 'evidence' is available only from commercial organisation

One of the more serious issues is, I believe, that much of the evidence is only available from commercial corporations that have been working on this and other issues, funding the research and publishing results.

Given the problems with posting of 'commercially oriented' materials it becomes a real problem. The only ways I can see to present their information is either break copyright or post links to these commercial sites.

I have no idea how we can present the clinical evidence and not, in some way, reference the organisations that supply that evidence - whatever their avowed objective (foundations, pure research funded via the public purse, commercial enterprises, government, etc.). —Preceding unsigned comment added by Lance1949 (talk • contribs) 02:06, 3 June 2009 (UTC)

Exaggeration

Women do not experience "complete" shutdown of the reproductive system at menopause, and this statement is a gross exaggeration. In both men and women, the gametes and sex hormones decline, but the reproductive system does not totally shut down. The eggs are still viable in menopausal women, as are the sperm in middle-aged men. It's just that in menopause, the woman's estrogen is too low to effectively carry the baby, just as in andropause the man's testosterone is too low to for him to become erect in many cases and deliver the sperm. This (in my view) incorrect and somewhat sexist statement is mentioned repeatedly throughout the article. I am no expert on this topic, but I think this should be edited.--Greenhplover (talk) 01:52, 9 September 2012 (UTC)

And this: "Some researchers prefer the term "androgen deficiency of the aging male" ("ADAM"), to more accurately reflect the fact that the loss of testosterone production is gradual and asymptotic (in contrast to the more abrupt change associated with menopause.) The "D" is sometimes given as "decline" instead of "deficiency". In some contexts, the term "partial androgen deficiency in aging males" ("PADAM") is used instead."

I don't think most middle-aged men with erectile disfunction caused by the lack of testosterone would say that this condition is asymptomatic either. This article reeks of bias and sexism. --Greenhplover (talk) 02:04, 9 September 2012 (UTC)

External links modified

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Testosterone levels

User:Plmokg22345 please discuss your concerns here. Thanks. Jytdog (talk) 03:09, 8 October 2016 (UTC) @Jytdog: I had this ref https://www.researchgate.net/publication/291337500_The_Aging_Male_Testofen_a_specialised_Trigonella_foenum-graecum_seed_extract_reduces_age-related_symptoms_of_androgen_decrease_increases_testosterone_levels_and_improves_sexual_function_in_healthy_agi checked by users on https://en.wikipedia.org/wiki/Wikipedia:New_contributors%27_help_chat and every one there stated it was a secondary source so I so do not buy your reason for getting ride of it — Preceding unsigned comment added by Plmokg22345 (talk • contribs) 16:45, 8 October 2016 (UTC)

primary source. Not valuable for health content. A link to a no-longer-existent chat is not helpful. Again, see the actual definitions in MEDRS. The Rao paper, is one where "authors directly participated in the research or documented their personal experiences. They examined the patients, injected the rats, filled the test tubes, or at least supervised those who did." The giveaway is the "Materials and Methods" section where they describe the actual experiments they did. If a review paper has such a section, they will describe how they selected papers to include, and nothing more. Jytdog (talk) 16:52, 8 October 2016 (UTC)

@Jytdog: they quoted other studies in there paper notaspy stated in this context it is a secondary source — Preceding unsigned comment added by Plmokg22345 (talk • contribs) 17:11, 8 October 2016 (UTC)

now being discussed at Wikipedia_talk:WikiProject_Medicine#articles_related_to_Ageing Jytdog (talk) 18:28, 8 October 2016 (UTC)

Late-onset hypogonadism

This article was redirected to Late-onset hypogonadism, but I think there may be enough material to at least consider a merge. In particular, for non-human mammals see Lincoln (2002).[1] Thank you. Praemonitus (talk) 20:26, 20 December 2016 (UTC)

It looks like the answer is a unilateral no without discussion. Very well. Note that this page was the redirect source for Irritable male syndrome and indirectly from the Grumpy Old Men page, yet contains no mention of these likely search terms. Wikipedia should be more helpful to those seeking information of this nature. Praemonitus (talk) 02:58, 22 December 2016 (UTC)

It is not clear to me what your complaint is. What is it? Jytdog (talk) 04:32, 22 December 2016 (UTC)

If I search for a term in an encyclopedia and reach a page, I expect that specific term to be discussed in some form, even if just to say it's a colloquial name suggested to be related in some manner to the condition. Why is that unclear? Grandma goes looking for "grumpy old man". What does she find out? She's directed to "Irritable male syndrome" and ends up on this page, but it says nothing about moodiness or argumentative behavior in older males. Instead, she wanders off and looks for other sources. Praemonitus (talk) 05:54, 22 December 2016 (UTC)

well there are huge issues about Wikipedia's search function that this raises, that go way beyond this particular article. The whole "irritable male syndrome" applied to humans is basically pseudoscience at worst and mogrel pop science at best (on the level of bullshit of "we only use 10% of our brains" which is a neuromyth), and we don't want to feed Grandma pseudoscience. I tried to remove anything that would lead her there. Jytdog (talk) 06:22, 22 December 2016 (UTC)

Caution: Hormone therapy not recommended

Because of life-threatening side effects, a hormone therapy is not recommended in the medical world: Marc B. Garnick. Testosterone Replacement Therapy Faces FDA Scrutiny. In: JAMA. 313, 2015, page 563 https://jamanetwork.com/journals/jama/article-abstract/2042936 Maybe U.S. doctors recommend hormone therapies in that case; European doctors don't. — Preceding unsigned comment added by 2003:8C:4C6B:DD00:89A:6558:226B:3F30 (talk) 16:36, 8 February 2017 (UTC)

Older age does not cause testosterone levels to decline in healthy men (australian research)

https://www.sciencedaily.com/releases/2011/06/110607121129.htm

Two study centers in Australia recruited 325 men over the age of 40 (median age, 60) who had self-reported excellent health and no symptom complaints. To test blood testosterone levels, the researchers took blood samples from the men nine times over three months. They excluded men from the study who took medications that affect testosterone.

Obesity caused a mild and clinically unimportant lowering of blood testosterone levels, the investigators reported. Age had no effect on testosterone level.

According to this research there is no connection between age and testosterone level.

Age-related testosterone decline in a Brazilian cohort of healthy military men

https://doi.org/10.1590/s1677-55382011000500004 https://www.ncbi.nlm.nih.gov/pubmed/22099270

In order to evaluate age-related changes in total testosterone levels, the concentration of this hormone was analyzed in the different age groups. In this regard, a progressive reduction in serum total testosterone levels was observed across age groups, with the mean testosterone value observed for younger men (821.1 ng/dL; age group < 40 years) being almost twice as high as the levels found for individuals belonging to the older age group (436.6 ng/dL; age group > 70 years).

Late-onset hypogonadism: Current concepts and controversies of pathogenesis, diagnosis and treatment (very important for understanding the problem)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955328/ https://www.ncbi.nlm.nih.gov/pubmed/24407185

Testicular function declines somewhat with advancing age, but the purely age-dependent change is usually small and probably of the same magnitude as that of other organs of the body. This is in clear contrast to the ovary, which undergoes a rapid functional involution at menopause. It is therefore counterintuitive to draw any parallels between the ageing-related changes in testicular and ovarian function. Total number of Sertoli and Leydig cells decreases to around half of that of the young testis. The concomitant increase in pituitary gonadotrophin secretion indicates the primary testicular nature of these alterations, and this compensatory response is able to minimize the decline of testicular function in most ageing men.

The concentration of serum T reaches its maximum around 25–30 years of age and starts a slow steady decline thereafter at a rate of about 1% per year. A recent longitudinal study showed that serum total T decreases between 55 and 68 years of age by 1.4% per year, free T by 2.7%, while SHBG increased at the same time by 2.7%. It is noteworthy that the aging-related decline of T shows great inter individual variability, with about 20% on men over 60 years having serum T in the upper normal range of young men, and about 20% being below the reference range, and even a larger proportion of men have their bioavailable T in the subnormal range. Hence the latter decreases more than total T, by about 2%–3% per year although the average free T level still remains within the normal range in most men. The decline of T purely due to biological ageing is primary, i.e., caused by testicular failure, and it is therefore accompanied by a reciprocal increase in luteinizing hormone (LH) secretion.

Another complexity to the age-related changes in T levels is brought about by the associated weight gain and deterioration of general health owing to chronic diseases-such as diabetes, hypertension, cardiac, hepatic or renal failure, chronic obstructive lung disease and inflammatory arthritis. Moreover, the medications associated with these disorders, such as opiates and glucocorticoids, are partially responsible for the decreased T through actions on LH secretory dynamics. T production can be considered a good indicator of a man's general health, which decreases in response to a variety of stressors. High body mass index (BMI) can be regarded to provide a read-out for metabolic stress, and its suppressive effect on T levels is much greater than that of chronological age. Serum T in a man with BMI >30 kg m–2 is, on average, 30% lower than that of a man with BMI <25 kg m–2, at any age, which is more that the purely age-dependent decrease between 40 and 80 years. The mechanism of this effect is unknown, but it is apparently linked to the increased negative feedback inhibition of gonadotropin secretion by adipose tissue-derived estrogens, leptin and cytikones/adipokines. A similar, though milder, suppression of T secretion is observed in men with chronic illnesses. Curiously, the decrease in T secretion associated with obesity and chronic illness is not associated with compensatory increase in gonadotropin levels, thus indicating a secondary central mechanism for the disturbance. Obesity as the cause of low T in ageing men is more common that chronological age; in the EMAS study, 73% of men fulfilling the criteria of LOH were obese or overweight.

This study shows the existence of a compensatory mechanism supporting the concentration of testosterone during aging. According to this study the main reason for the decrease in testosterone concentration during aging is an unhealthy lifestyle leading to various diseases, including obesity. It is very important for understanding the problem.

"aging" (used 9 times), or "ageing" (used 4 times)?

Let's do something about it. 85.193.242.185 (talk) 13:00, 1 March 2020 (UTC)

Both options are considered correct. But aging is formed in compliance with the rules of using "-ing". — Preceding unsigned comment added by 37.78.14.206 (talk) 19:22, 1 March 2020 (UTC)

It is like saying that both "color" and "colour" are correct. I am aware of the underlying grammar. However, we shouldn't mix British and American English - look here. 85.193.242.185 (talk) 22:13, 2 March 2020 (UTC)