Talk:Fentanyl

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Fentanyl.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

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Place brand name of narcan to any mention of naloxone on page[edit]

Could help bring awareness, as many know what narcan is but not naloxone 209.242.39.40 (talk) 02:48, 12 August 2022 (UTC)[reply]

I had heard of naloxone, but not Narcan, before this comment. Ei9ther way, drugs are conventionally named after their generic name. –LaundryPizza03 (d c̄) 15:15, 12 August 2022 (UTC)[reply]

I've added a brief mention of the brand name in the overdose section discussing use of naloxone. I think this mostly clears up the issue. JumbledPasta (talk) 06:05, 28 January 2023 (UTC)[reply]

Article fails to identify why fentanyl causes respiratory depression[edit]

Under Adverse effects, the article should indicate that fentanyl's high propensity to cause significant respiratory depression is likely due in part to its biased agonism/functional selectivity for β-arrestin-2 at the MOR. This liability is compounded by the fact that fentanyl exhibits extremely high binding affinity to the MOR.

Podlewska, S.; Bugno, R.; Kudla, L.; Bojarski, A.J.; Przewlocki, R. Molecular Modeling of µ Opioid Receptor Ligands with Various Functional Properties: PZM21, SR-17018, Morphine, and Fentanyl—Simulated Interaction Patterns Confronted with Experimental Data. Molecules 2020, 25, 4636. https://doi.org/10.3390/molecules25204636 (See table 1)

Stahl EL, Schmid CL, Acevedo-Canabal A, et al. G protein signaling-biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists. Proceedings of the National Academy of Sciences of the United States of America. 2021 Nov;118(48):e2102178118. DOI: 10.1073/pnas.2102178118. PMID: 34819362; PMCID: PMC8640941. 2601:6C5:300:B230:3CF1:F729:3B3D:C887 (talk) 06:11, 19 March 2023 (UTC)[reply]

"Possible poisonings through secondary exposure"[edit]

This seems somewhat misleading, given what the section actually says about the likelihood of someone being affected by simply coming into contact with a person who has taken or overdosed on fentanyl. Such poisonings do not appear to be possible.

The heading was previously "Misconceptions and moral panic", which is probably too far in the other direction. What's a good heading for this? Belbury (talk) 15:27, 10 May 2023 (UTC)[reply]

"Secondary contact and inhalation exposure" ? — Shibbolethink ^(♔ ^♕) 21:03, 10 May 2023 (UTC)[reply]

Inacurate[edit]

I don’t see the statements are all supported when reading the references, and the posting seems to be written intentionally to diminish the problems with Fentanyl, suggesting the possibly this was written by someone with interests in the Fentanyl industry. How is anyone to know?

It would be nice if someone could provide a more evidenced discussion of Fentanyl. 2600:1702:3070:7600:8CF1:DF03:8998:3694 (talk) 07:39, 5 August 2023 (UTC)[reply]

What statements? What references? What posting? Meters (talk) 08:53, 5 August 2023 (UTC)[reply]

You claim the following: "...[T]he posting seems to be written intentionally to diminish the problems with [f]entanyl, suggesting the possibly this was written by someone with interests in the [pharmaceutical] industry". First, what are these problems you claim exist with fentanyl? Second, please explain how this article appears to be written by the pharmaceutical industry. I cannot find any significant adverse reactions to fentanyl that exist which have been not documented in some degree by this article. Furthermore, I've struggled to find this alleged bias you speak of. I looked at the user names of recent contributors to this article and have found none with names like User:JanssenPharmaceuticaRep or similar. There is little to suggest that fentanyl is any but a safe and effective medication when its carefully used according to preparation labelling and dispensed under the supervision of a physician for a valid medical purpose. If you can find anything to back-up your claims, please let me know. Irruptive Creditor (talk) 21:37, 28 October 2023 (UTC)[reply]

The OP has had almost three months to respond, so there's not much point in asking for clarification of the drive-by complaint. Meters (talk) 21:53, 28 October 2023 (UTC)[reply]

Eh, that's true. Irruptive Creditor (talk) 07:03, 30 October 2023 (UTC)[reply]

2mg lethal Fentanyl amount viewed against a US Penny[edit]

I would have thought something more internationally recognisable than a US penny would have been better for physical size comparison like a ruler with metric and imperial measurements present. Many people have no idea of the sizing of US coins, especially those who live elsewhere. I realise pictures showing a physical difference may be hard to find, so perhaps the metric size of a US penny could be put in brackets next to it. 81.174.158.84 (talk) 04:53, 8 August 2023 (UTC)[reply]

Done I had done this for a previous article about an insect, but I don't remember which one. –LaundryPizza03 (d c̄) 18:53, 8 August 2023 (UTC)[reply]

Many thanks LaundryPizza03,

Stv 81.174.158.84 (talk) 16:01, 12 August 2023 (UTC)[reply]

I went ahead and removed that image from this (and other) articles. Unless I'm missing something, the source is just a photo gellery with no description; the amount and the claim that it's a lethal dose seem to be unsourced. –dlthewave ☎ 18:22, 15 August 2023 (UTC)[reply]

FENTANIL???[edit]

Perhaps this is correct - can anyone provide a citation? BeingObjective (talk) 21:36, 4 November 2023 (UTC)[reply]

Are you questioning the validity of that spelling? There are numerous sources that use the "i" spelling. If you want a source then just add one of them. Meters (talk) 22:40, 4 November 2023 (UTC)[reply]

Indeedy - and in the US and in a clinical setting - ME - I have not seen the variant spelling - my OR world might be very small - but I ran numerous checks - it is NOT that big of a deal - I guess. BeingObjective (talk) 22:48, 4 November 2023 (UTC)[reply]

Several Wikipedians have stated this is so - not a one has given a legitimate source of the variant - BeingObjective (talk) 22:50, 4 November 2023 (UTC)[reply]

@BeingObjective:Looking at the results of my cursory Google search more closely, I'm not seeing any solid sources for this spelling. There are quite a few search results that seem to show "fentanil" as appearing on a web page when actually it does not. It appears that the term is being added to page descriptions to catch misspelled searches. Other pages do use "fentanil" but with wording very similar to Wikipedia's "Fentanyl, also spelled fentanil," and may just copies from Wikipedia. This article has included the supposed alternate spelling since 2010, when it was added by an IP [1]. If no-one can come up with a solid reliable source that cannot be a case of citogenesis then WP:BEBOLD and remove it. Meters (talk) 03:16, 5 November 2023 (UTC)[reply]

Many thanks for this - it might seem to some a trivial matter - but I was fairly certain it has no solid bases - I tried to correct this previously and got really beaten up - I will likely just leave it for some future individual - I have so many Admin warnings I'm trying to play super nice - many thanks again. BeingObjective (talk) 03:37, 5 November 2023 (UTC)[reply]

I made the small change - I am expecting to be kicked off for edit warring - I really do not see this as that - it has been a fairly painful WP initiation - I do feel rather attacked -- BeingObjective (talk) 15:09, 5 November 2023 (UTC)[reply]

I think it's a valid, straightforward change. There are fentanyl analogues that end in “-nil”, so maybe that's where the confusion came from. Larry Hockett (Talk) 15:53, 5 November 2023 (UTC)[reply]

Thanks so much for the comment - it is appreciated.

Kind regards BeingObjective (talk) 15:56, 5 November 2023 (UTC)[reply]

Sedation and analgesia in intensive therapy:

Other opioid agents used in IT are: fentanil, alfentanil, sufentanil.

The search for the "next" euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning:

A detailed review on the chemistry and pharmacology of non-fentanil novel synthetic opioid receptor agonists, [...]

It occurs infrequently enough that it probably doesn't belong in the first sentence, as long as the redirect from Fentanil stays. Kimen8 (talk) 22:49, 5 November 2023 (UTC)[reply]

I'm simply fine with that - many thanks. BeingObjective (talk) 22:52, 5 November 2023 (UTC)[reply]