Talk:XY gonadal dysgenesis

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if XY female mate with XY male?[edit]

A very intresting question came to my mind. If somehow by giving estrogen and other female hormones will it produce normal baby if it mates with an normal male?

There are no ovaries, hence no eggs, no pregnancy, no baby. alteripse 01:43, 30 March 2006 (UTC)[reply]

The only ways for a Swyer to have a baby are to either use someone else's embryo, or have a clone of themselves implanted through IV. (yes, I have pondered this kind of thing. I am a Swyer ;)) --60.229.153.253 10:47, 24 February 2007 (UTC) (Addition to the above: I don't know how advanced biology is, but some day it could be possible to clone a virile male version of myself by adding the SRY gene! That would be sweet)--138.130.124.108 05:47, 12 March 2007 (UTC)[reply]

I don't think that by taking another woman's egg, extracting her genetic material, and inserting the genetic material of a Swyer patient, the baby would necessarily be a clone. Before you insert the Swyer woman's DNA, it would have to be split in half right...because that is how natural embryos are formed. Half the female's DNA, and half the male's DNA. to make the full set. So perhaps, the DNA of the Swyer patient can be extracted from a somatic/body cell, split in half, combined with the genetic material of one sperm, and inserted into a previously emptied donor egg. Does this make sense to anyone, or am I not "getting" it? —Preceding unsigned comment added by 70.75.45.45 (talk) 02:05, 27 August 2009 (UTC)[reply]

I think we need an article on gonadal dysgenesis[edit]

Swyer syndrome is one type of gonadal dysgenesis. Rather than confusing mentions of a random assortment of some of the other forms of intersex or gonadal dysgenesis, we need an article on gonadal dysgenesis that explains the term and lists systematically the major forms. In the meantime, I parked some of Ekem's recent additions here because I think they confuse rather than inform the reader. The section either needs to be more complete or systematic (which would be longer than the rest of the article) or it needs to be part of an article on all the forms of gonadal dysgenesis. alteripse 15:50, 23 June 2006 (UTC)[reply]

Removed material:

Swyer syndrome results from a failure of one of the earliest stages of differentiation of a genetic male: translation of the SRY gene to initiate testicular development. In a minority of cases of apparent Swyer syndrome, some other very early defect of testicular development (testicular dysgenesis) occurs. Since estrogens are made from androgens, any severe defect of androgen production (e.g., congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency) will also produce estrogen deficiency and result in a failure of pubertal development in a girl with an XY karyotype. On the other hand, a defect of androgen action (e.g., androgen insensitivity syndrome) is readily distinguished because the breasts begin to develop normally without much delay, though pubic hair may be minimal.

There is a condition in 46,XX females where the ovaries fail to develop or become atretic prior to puberty: XX gonadal dysgenesis.

Anorchia refers to a condition in males whose testicular development arrests prior to birth but after the reproductive system has been masculinized.

Diagnosed with Swyer, but having secondary sex characteristics[edit]

I was reciently diagnosed with Swyers, but I noticed that the artice says there shoudn't be any development of secondary sex characteristics(Aka breasts, and pubic hair) however, I have both.. It it still a form of Swyer? —Preceding unsigned comment added by Kairnaola (talkcontribs) 15:01, 5 November 2008 (UTC)[reply]

I think so, I mean I have pubic hair too and I have been diagnosed with it. Pubic hair is caused by testosterone which we can get from our andrenal glands. Breasts- well, I have "breast buds". I am not sure how they came about though, I'm not a sciencey scienceman. --58.178.248.35 (talk) 01:56, 20 January 2009 (UTC)[reply]

Contradiction regarding breast development[edit]

The intro says that breasts develop on their own if the streaks are not removed. The "Treatment" section, on the other hand, suggests that breasts fail to develop without estrogen replacement. Sounds like a contradiction to me... --NetRolller 3D 02:56, 20 August 2010 (UTC)[reply]

Article has been updated since your concern, and no longer contradicts itself. For the record though, as is now expressed by the article, by default there is no breast development in Swyer Syndrome - lack of ovaries means your adrenal glands are the only source of sex hormones... which is not sufficient to induce breast development (but is enough to get pubic hair). corvus.ag (talk) 19:44, 1 May 2011 (UTC)[reply]


Doesn't Jamie Lee Curtis have this condition?--Kleinr (talk) 23:14, 21 September 2011 (UTC)[reply]

Rare case of breast development and menstruation in Swyer Syndrome patients.[edit]

I’m not entirely sure where you can put this but I think this is some good information to add here.

[1]

— Preceding unsigned comment added by CycoMa (talkcontribs)

__

References

There have been cases of women with Swyer syndrome having ovaries or ovarian tissue.[edit]

I think it should be added.


https://link.springer.com/article/10.1007/BF00569712

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680992/

https://www.sciencedirect.com/science/article/abs/pii/0002937871902225 — Preceding unsigned comment added by CycoMa (talkcontribs) 12:31, 3 August 2020 (UTC)[reply]

Per WP:MEDRS, stick to WP:MEDRS-compliant sources for this material. This means, for example, avoiding primary sources (WP:PRIMARY). Also see what WP:SCHOLARSHIP states. Flyer22 Frozen (talk) 21:52, 3 August 2020 (UTC)[reply]

These sources might come in handy[edit]

This article seems very short and needs more information. So I found a bunch of sources that might come in handy, not sure where to put them.

You don’t have to add all of these and there are probably some flaws within these sources I’m merely mentioning them for info.


Found 2 sources mentioning that 10-15% of cases are caused by mutation in SRY gene.

https://www.google.com/books/edition/Clinical_Gynecologic_Endocrinology_and_I/Ll73ZsBKLkwC?hl=en&gbpv=1&dq=Swyer+syndrome&pg=PA365&printsec=frontcover

https://rarediseases.org/rare-diseases/swyer-syndrome/

The rate of tumor development wasn’t mentioned.

https://fertilitypedia.org/edu/diagnoses/swyer-syndrome

https://wjso.biomedcentral.com/articles/10.1186/1477-7819-5-71



The article doesn’t mention that Hormone replacement therapy also helps reduce the risk of reduced bone density and doesn’t mention anything about nerve problems or it having some connections to campomelic dysplasia.

https://www.google.com/books/edition/Genetics_of_Bone_Biology_and_Skeletal_Di/tmx_CwAAQBAJ?hl=en&gbpv=1&dq=swyer+syndrome+osteoporosis&pg=PA6&printsec=frontcover

https://www.endocrine-abstracts.org/ea/0037/ea0037ep1336

https://medlineplus.gov/genetics/condition/swyer-syndrome/


I think Jeanne Nollman should be mentioned in this article as well since she helped out in intersex activism and was even mentioned on a episode of Mystery Diagnosis.

https://isna.org/node/1082/

http://www.tv.com/shows/mystery-diagnosis/the-woman-with-unusual-dna-1381272/


I found these sources about Gerald Swyer.

https://www.google.com/books/edition/Dr_Gerald_Swyer/3uwYNQEACAAJ?hl=en

https://www.google.com/books/edition/The_Fertility_Doctor/WiW1qeQxYM8C?hl=en&gbpv=1&dq=Gerald+Swyer.&pg=PA212&printsec=frontcover

https://history.rcplondon.ac.uk/inspiring-physicians/gerald-isaac-macdonald-swyer


Also the article doesn’t mention anything about menstruation, even tho there have been documented cases like I shown earlier in the talk page.



I also found some more sources that may or may not come in handy.

https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/j.1471-0528.2008.01703.x

https://www.ecronicon.com/ecgy/pdf/ECGY-08-00329.pdf

https://reference.medscape.com/viewarticle/923606_5


Do as you please with these sources. — Preceding unsigned comment added by CycoMa (talkcontribs) 06:00, 12 September 2020 (UTC)[reply]

Primary source[edit]

I just realized something [this source] is a primary source. Sure primary sources are okay at times but a source like that isn’t ideal for article like this.CycoMa (talk) 17:18, 5 July 2021 (UTC)[reply]

Factual error regarding science paper reference/ citation.[edit]

There is apparent misreading of a science paper that has been included in this article. It resulted in a false statement that reads:

"There has been a case of unassisted pregnancy in one woman with XY gonadal dysgenesis".

The science paper literally contradicts that statement as well.

If you reread the article, the woman who is the topic of said article does not have XY gonadal dysgenesis. If you do a search of the article (usually ctrl F), you will realize that XY gonadal dysgenesis is indeed mentioned. It is not however implied that the subject of the article has it! It also makes reference to her daughter having XY gonadal dysgenesis.

It is citation 4 if you look at the end of the article. Please fact check me (this is the reason I did not just delete the content). I think it was not a vandalization! I think it is a simple misreading. 92.237.107.235 (talk) 21:43, 20 January 2024 (UTC)[reply]